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Herbs are the most important products in natural resources which directly have a positive impact on the lives of people. Many of the drugs we use are directly or indirectly from herbal medicinal products. Fars province in southern Iran, with an area of 133000 square kilometers is one of the largest provinces of the country. There are different climates in the province that has caused it to be a pioneer at production and use of medicinal plants in the country, as it is the largest exporter of medicinal plants in the country. In this study, an overview of the most important medicinal species in this province has been dealt with.