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In retrosynthetic analysis, a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. This disconnection approach to synthesis is now a fundamental part of every organic synthesis course. Brimming with new examples, synthetic pathways, and updated material to reflect 25 years of advances in organic synthesis, this fully revised and updated second edition of the classic textbook introduces this important technique to help final year undergraduates and postgraduate organic chemistry students design their own organic syntheses.